�With the revolutionary Randox HDL and LDL clearance method, division of the lipid profile, specificity of testing and accuracy of diagnosis is vastly improved. This has replaced traditional assessment of cardiovascular disease (CVD) peril which oftentimes provided inaccurate and insufficient information for the clinician, possibly in the lead to misdiagnosis of the patient.
The lipid profile, a group of tests performed to determine risk of exposure of CVD, comprises tally cholesterol, triglycerides, high denseness lipoproteins (HDL) and humiliated density lipoproteins (LDL) cholesterol and extra parameters such as apolipoproteins. LDL cholesterin transports cholesterin to the cells for utilisation and plays a central role in the development of atherosclerotic lesions. It is generally regarded as the most important risk factor for CVD. HDL cholesterol, a damaging risk constituent, transports cholesterol from the cells to the liver for metamorphosis and riddance from the body. Regular assessment of these parameters is necessary to instal risk and, if necessary, monitor handling.
Traditional LDL cholesterol measurement based on the Friedewald equation deliberate from three separate assays, requires a fasting affected role sample and inaccurately estimates cholesterol in hypertriglyceridaemia resulting in misclassification of up to 50% of patient samples. Direct masking methods are a recent development in HDL cholesterol analysis in which non-HDL molecules are masked initially and then HDL cholesterol is measured. However, these methods underestimate HDL levels in hypertriglyceridaemia. This is ascribable to the fact that in abnormal samples, the composition of the lipoproteins is altered by these high levels of triglycerides and consequently cannot be distinguished during the masking piece process. Furthermore, these methods show poor agreement with ultracentrifugation employed in gold standard reference laboratories.
The Randox HDL and LDL clearance methods overcome these issues by completely removing the non-HDL/LDL molecules before directly measuring the HDL/LDL cholesterol in the sampling. It is highly specific and therefore eliminates problems associated with hypertriglyceridaemia. The Randox HDL and LDL clearance methods show fantabulous correlation with ultracentrifugation highlight its superior accuracy.
Randox HDL and LDL clearance method kits are liquid, ready to use, automatable assays with a broad measuring range and good stability. Accurate HDL and LDL cholesterin measurement is vital to establish CVD risk, and to determine therapeutic personal effects. By victimisation Randox direct clearance methods you canful be assured of a more accurate diagnosis and confidence in your results.
About Randox
Randox is an international diagnostics company, headquartered in the UK. Randox develop, manufacture and market clinical symptomatic products worldwide. Core products are: Biochip Array Technology; clinical chemistry analysers and reagents; calibre controls and EQA; recombinant proteins and antibodies.
Randox Laboratories
Diamond Road
Crumlin
Co. Antrim BT29 4QY
United Kingdom
http://www.randox.com
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